PROTAC IRAK4 degrader-10

PROTAC IRAK4 degrader-10

• CAS Number: 3033829-95-4
• UNSPSC Description: PROTAC IRAK4 degrader-10 (compound 10) is an oral active PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 95.94% and the DC50 of 7.68 nM in HEK293 cells (Sturcture Note:(Blue: Cereblon ligand, Black: linker；Pink: IRAK4 ligand)[1].
• Target Antigen: IRAK; PROTACs
• Type: Reference compound
• Related Pathways: Immunology/Inflammation;PROTAC
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/protac-irak4-degrader-10.html
• Smiles: O=C(C1=NC(C2C(F)(F)C2)=CC=C1)NC3=CN4C(C(F)=C3C(C)(O)C)=NC(C5CCN(CC6CCN(C7=CC8=C(C(N(C(CC9)C(NC9=O)=O)C8=O)=O)C=C7)CC6)CC5)=C4
• Molecular Weight: 826.86
• References & Citations: [1]Zhang Xuejūn, et al. Imidazopyridines as IRAK4 degradants and uses thereof. CN117777126A. 2024-03-29.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported