PROTAC IRAK4 degrader-11
CAT:
804-HY-158760
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
PROTAC IRAK4 degrader-11
- UNSPSC Description: PROTAC IRAK4 degrader-11 (compound 15) is PROTAC based on Cereblon ligand, and induces the degradation of IRAK4 with maximum degradation of 96.25% and the DC50 of 2.29 nM in HEK293 cells(Sturcture Note:(Blue: Cereblon ligand (HY-14658), Black: linker；Pink: IRAK4 inhibitor)[1].
- Target Antigen: IRAK; PROTACs
- Type: Reference compound
- Related Pathways: Immunology/Inflammation;PROTAC
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/protac-irak4-degrader-11.html
- Smiles: O=C(C1=CC=CC([C@@H]2CC2(F)F)=N1)NC3=CN4C=C(C5CCN(CC6CN(C6)C7=CC=C8C(N(C9C(NC(CC9)=O)=O)C(C8=C7)=O)=O)CC5)N=C4C(F)=C3C(C)(C)O
- Molecular Weight: 798.81
- References & Citations: [1]Zhang Xuejun, et al. Imidazopyridines as IRAK4 degradants and uses thereof. CN117777126A. 2024-03-29.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported