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BMS-351

CAT: 0804-HY-117529Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117529Size:1 Each
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Description
BMS-351 (compound 18) is a potent, oral active, nonsteroidal CYP17A1 lyase inhibitor with the IC50 values of 19 nM and 4 nM aganist human CYP17A1 and cynomolgus monkeys CYP17A1, respectively. BMS-351 can be used for the study of castration-resistant prostate cancer[1].
CAS Number
1370001-71-0
UNSPSC
12352005
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/bms-351.html
Smiles
FC(F)(CN1C=NC2=C1C=CC=C2C3=C(C)C=CN=C3)F
Molecular Formula
C15H12F3N3
Molecular Weight
291.27
References & Citations
[1]Huang A, et al. Discovery of the Selective CYP17A1 Lyase Inhibitor BMS-351 for the Treatment of Prostate Cancer. ACS Med Chem Lett. 2015;7 (1) :40-45. Published 2015 Dec 2.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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