CPN-351 (TFA)

• Description:

  CPN-351 TFA (compound 9a), a pentapeptide, is a selective antagonist of human NMUR1 with a pA2 of 7.35. The antagonistic effect of CPN-351 TFA on human NMUR1 is 10 times higher than that on NMUR2. CPN-351 TFA can be used in the study of inflammation[1]. X

• UNSPSC:

  12352209

• Target:

  Neuromedin U Receptor (NMUR)

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Purity:

  99.06

• Smiles:

  CN([C@H](C(N[C@@](CC1=CC=CC=C1)(C(N[C@H](C(N2CCC[C@H]2C(N[C@H](C(N)=O)CCCNC(N)=N)=O)=O)CCCNC(N)=N)=O)C)=O)CC3=CNC4=C3C=CC=C4)C(CC5=CC=CS5)=O.OC(C(F)(F)F)=O.

• Molecular Formula:

  C45H61N13O6S.xC2HF3O2

• Molecular Weight:

  912.11 (free base)

• References & Citations:

  [1]Takayama K, et al. Discovery of a Pentapeptide Antagonist to Human Neuromedin U Receptor 1. ACS Med Chem Lett. 2024 May 24;15 (6) :885-891.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  No Development Reported

• Isoform:

  NMUR1