BMS-182264

CAT: 0804-HY-120540Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-120540Size:1 Each
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Description
BMS-182264 is a highly selective ATP-sensitive potassium channel agonist. BMS-182264 promotes potassium efflux and membrane hyperpolarization to induce smooth muscle relaxation and vasodilation. BMS-182264 is promising for research of cardiovascular diseases such as hypertension and myocardial ischemia[1][2].
CAS Number
[127749-54-6]
UNSPSC
12352005
Target
Potassium Channel
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cardiovascular Disease
Smiles
N#CN/C(NC(C(C)(C)C)C)=N\C1=CC=C(C=C1)C#N
Molecular Formula
C15H19N5
Molecular Weight
269.34
References & Citations
[1]Dickinson KE, et al. Identification of [3H]P1075 binding sites and P1075-activated K+ currents in ovine choroid plexus cells. Eur J Pharmacol. 1998 Mar 12;345 (1) :97-101.|[2]Atwal KS. Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers. J Cardiovasc Pharmacol. 1994;24 Suppl 4:S12-7.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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