BMS-182264

• Description :

  BMS-182264 is a highly selective ATP-sensitive potassium channel agonist. BMS-182264 promotes potassium efflux and membrane hyperpolarization to induce smooth muscle relaxation and vasodilation. BMS-182264 is promising for research of cardiovascular diseases such as hypertension and myocardial ischemia[1][2].

• UNSPSC :

  12352005

• Target :

  Potassium Channel

• Related Pathways :

  Membrane Transporter/Ion Channel

• Field of Research :

  Cardiovascular Disease

• Smiles :

  N#CN/C(NC(C(C)(C)C)C)=N\C1=CC=C(C=C1)C#N

• Molecular Formula :

  C15H19N5

• Molecular Weight :

  269.34

• References & Citations :

  [1]Dickinson KE, et al. Identification of [3H]P1075 binding sites and P1075-activated K+ currents in ovine choroid plexus cells. Eur J Pharmacol. 1998 Mar 12;345 (1) :97-101.|[2]Atwal KS. Pharmacology and structure-activity relationships for KATP modulators: tissue-selective KATP openers. J Cardiovasc Pharmacol. 1994;24 Suppl 4:S12-7.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [127749-54-6]