TNP-351

• Description :

  TNP-351 is an antifolate. TNP-351, a dihydrofolate reductase (DHFR) inhibitor, has potent antitumor activity against not only leukemia cells but also solid tumor cells in vitro and in vivo[1].

• UNSPSC :

  12352005

• Target :

  Antifolate

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/tnp-351.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(O)CC[C@@H](C(O)=O)NC(C1=CC=C(CCCC2=CNC3=NC(N)=NC(N)=C32)C=C1)=O

• Molecular Formula :

  C21H24N6O5

• Molecular Weight :

  440.45

• References & Citations :

  [1]F Itoh , et al. Novel pyrrolo[2,3-d]pyrimidine Antifolate TNP-351: Cytotoxic Effect on Methotrexate-Resistant CCRF-CEM Cells and Inhibition of Transformylases of De Novo Purine Biosynthesis. Cancer Chemother Pharmacol. 1994;34 (4) :273-9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• CAS Number :

  [125991-51-7]