BMS-986126

• Description:

  BMS-986126 is a potent, selective, and orally active IRAK4 inhibitor (IC50 = 5.3 nM) . BMS-986126 broadly inhibits MyD88-dependent signaling pathways. BMS-986126 demonstrates robust activity in the MRL/lpr and NZB/NZW murine models of lupus, inhibiting multiple pathogenic responses. BMS-986126 can be used for autoimmune diseases research, such as lupus erythematosus (SLE) [1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  ERK; Interleukin Related; IRAK; NF-κB; Toll-like Receptor (TLR)

• Related Pathways:

  Immunology/Inflammation; MAPK/ERK Pathway; NF-κB; Stem Cell/Wnt

• Field of Research:

  Inflammation/Immunology

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)(O)[C@H](F)CNC(C(C(NC1CC1)=C2)=CN=C2NC3=NC4=C(C=NC=C4)C=C3)=O

• Molecular Formula:

  C22H25FN6O2

• Molecular Weight:

  424.47

• Precautions:

  P261-P280-P302+P352

• References & Citations:

  [1]Shailesh Dudhgaonkar, et al. Selective IRAK4 Inhibition Attenuates Disease in Murine Lupus Models and Demonstrates Steroid Sparing Activity. J Immunol. 2017 Feb 1;198 (3) :1308-1319.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IRAK4

• CAS Number:

  [1610017-20-3]