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NADI-351

CAT: 0804-HY-164404-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-164404-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
NADI-351 is an orally active and potent Notch1 inhibitor that selectively disrupts Notch1 transcription complexes and reduces Notch1 recruitment to target genes. NADI-351 can be utilized in cancer research[1].
CAS Number
2503017-11-4
UNSPSC
12352005
Target
Notch
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nadi-351.html
Purity
99.83
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C/C(C1=CC(OC)=C(C(F)=C1)OCC2=NN=CN2)=C3C(N(C(S\3)=S)CC(N(C)C)=O)=O
Molecular Formula
C19H20FN5O4S2
Molecular Weight
465.52
References & Citations
[1]Alvarez-Trotta A, et al. Pharmacological Disruption of the Notch1 Transcriptional Complex Inhibits Tumor Growth by Selectively Targeting Cancer Stem Cells. Cancer Res. 2021 Jun 15;81 (12) :3347-3357.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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