CDD-1653

• UNSPSC Description:

  CDD-1653 is a potent and selective BMPR2 inhibitor (IC50=2.8 nM). CDD-1653 reduces the ability of ATP to bind to the kinase domain of BMPR2, thereby affecting the phosphorylation of SMAD1/5/8 transcription factors, which play a key role in the BMP signaling pathway. CDD-1653 can be used to study diseases related to the BMP signaling pathway[1].

• Target Antigen:

  TGF-β Receptor

• Type:

  Reference compound

• Related Pathways:

  TGF-beta/Smad

• Field of Research:

  Cancer; Others

• Assay Protocol:

  https://www.medchemexpress.com/cdd-1653.html

• Smiles:

  O=C1N(CCN(C1)C2=NC(NC3=CC=CC(S(=O)(N)=O)=C3)=NC=C2OC)C4=CC=CC=C4

• Molecular Weight:

  454.50

• References & Citations:

  [1]Modukuri R K, et al. Discovery of highly potent and BMPR2-selective kinase inhibitors using DNA-encoded chemical library screening[J]. Journal of Medicinal Chemistry, 2023, 66(3): 2143-2160.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3034216-44-6