CDD-1115

• Description :

  CDD-1115 is a potent, selective inhibitor of BMPR2 with IC50 of 1.8 nM, Kiapp of 6.2 nM. CDD-1115 inhibits bone morphogenetic protein (BMP) -mediated gene expression. BMP controls cellular processes across many tissue types, including the kidney, skeletal muscle, heart, and reproductive organs. BMP induces ectopic bone formation[1].

• UNSPSC :

  12352005

• Target :

  Anaplastic lymphoma kinase (ALK)

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Field of Research :

  Endocrinology; Cardiovascular Disease

• Smiles :

  NC(C1=CC=CC(CNC(C2=CC=C3N=C(C4=CC5=C(C=NC=C5)C=C4)N([C@H]6C[C@@H](CC6)C(NC)=O)C3=C2)=O)=C1)=O

• Molecular Formula :

  C32H30N6O3

• Molecular Weight :

  546.62

• References & Citations :

  [1]Modukuri RK, et al. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 Feb 9;66 (3) :2143-2160.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3034215-86-3]