CDD-2110

• Description :

  CDD-2210 is a STK33 inhibitor, with a Kd of 0.1 nM and an IC50 of 38 nM. CDD-2210 has relatively weak inhibitory effects on off-target kinases, with IC50 values of 1209 nM for CLK1, 917 nM for CLK2, 544 nM for CLK4, and 746 nM for RET. CDD-2210 can be used for the study of contraception[1].

• CAS Number :

  [3086535-49-8]

• Target :

  RET; STK33

• Related Pathways :

  Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

• Field of Research :

  Others

• Smiles :

  O=C(N1CCC(C1)N2CCC(CC2)C(NC)=O)C3=CC4=C(NN=C4C#CC5=C(C6=CC=CC=C6)C=CC=C5)C=C3

• Molecular Formula :

  C33H33N5O2

• Molecular Weight :

  531.65

• References & Citations :

  [1]Ku AF, et al. Reversible male contraception by targeted inhibition of serine/threonine kinase 33. Science. 2024 May 24;384 (6698) :885-890.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported