CDD-1431

• Description:

  CDD-1431 is a low-nanomolar selective kinase inhibitors of BMPR2, with Kiapp value of 20.6 nM. CDD-1431 suppresses BRE-reporter activity, with an IC50 of 4.87 μM. BMP controls cellular processes across many tissue types, including the kidney, skeletal muscle, heart, and reproductive organs. BMP induces ectopic bone formation[1].

• UNSPSC:

  12352005

• Target:

  TGF-β Receptor

• Related Pathways:

  TGF-beta/Smad

• Field of Research:

  Endocrinology; Cardiovascular Disease

• Smiles:

  COC (C=N1) =C (N2CCN (C3=CC=CC (CNC (C4=CC=C (CCC (NC) =O) C=C4) =O) =C3) CC2) N=C1NC5=CC (S (=O) (N) =O) =CC=C5

• Molecular Formula:

  C33H38N8O5S

• Molecular Weight:

  658.77

• References & Citations:

  [1]Modukuri RK, et al. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 Feb 9;66 (3) :2143-2160.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  3034216-31-1