CDD-1431

• Description :

  CDD-1431 is a low-nanomolar selective kinase inhibitors of BMPR2, with Kiapp value of 20.6 nM. CDD-1431 suppresses BRE-reporter activity, with an IC50 of 4.87 μM. BMP controls cellular processes across many tissue types, including the kidney, skeletal muscle, heart, and reproductive organs. BMP induces ectopic bone formation[1].

• UNSPSC :

  12352005

• Target :

  TGF-β Receptor

• Related Pathways :

  TGF-beta/Smad

• Field of Research :

  Endocrinology; Cardiovascular Disease

• Smiles :

  COC(C=N1)=C(N2CCN(C3=CC=CC(CNC(C4=CC=C(CCC(NC)=O)C=C4)=O)=C3)CC2)N=C1NC5=CC(S(=O)(N)=O)=CC=C5

• Molecular Formula :

  C33H38N8O5S

• Molecular Weight :

  658.77

• References & Citations :

  [1]Modukuri RK, et al. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 Feb 9;66 (3) :2143-2160.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [3034216-31-1]