CDD-1431

CAT: 0804-HY-171249Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-171249Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDD-1431 is a low-nanomolar selective kinase inhibitors of BMPR2, with Kiapp value of 20.6 nM. CDD-1431 suppresses BRE-reporter activity, with an IC50 of 4.87 μM. BMP controls cellular processes across many tissue types, including the kidney, skeletal muscle, heart, and reproductive organs. BMP induces ectopic bone formation[1].
CAS Number
[3034216-31-1]
UNSPSC
12352005
Target
TGF-β Receptor
Related Pathways
TGF-beta/Smad
Field of Research
Endocrinology; Cardiovascular Disease
Smiles
COC(C=N1)=C(N2CCN(C3=CC=CC(CNC(C4=CC=C(CCC(NC)=O)C=C4)=O)=C3)CC2)N=C1NC5=CC(S(=O)(N)=O)=CC=C5
Molecular Formula
C33H38N8O5S
Molecular Weight
658.77
References & Citations
[1]Modukuri RK, et al. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 Feb 9;66 (3) :2143-2160.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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