CDD-2211

• Description:

  CDD-2211 is a STK33 inhibitor, with a Kd of 0.018 nM and an IC50 of 5 nM. CDD-2211 has relatively weak inhibitory effects on off-target kinases, with IC50 values of 115 nM for CLK1, 48 nM for CLK2, 187 nM for CLK4, and 78 nM for RET. CDD-2211 can be used for the study of contraception[1].

• UNSPSC:

  12352005

• Target:

  RET; STK33

• Related Pathways:

  Cell Cycle/DNA Damage; Protein Tyrosine Kinase/RTK

• Field of Research:

  Others

• Smiles:

  O=C(N1C[C@@H](CC1)N(C)C)C2=CC=C3C(C(C#CC4=C(C5=CC=CC=C5)C=CC=C4)=NN3)=C2

• Molecular Formula:

  C28H26N4O

• Molecular Weight:

  434.53

• References & Citations:

  [1]Ku AF, et al. Reversible male contraception by targeted inhibition of serine/threonine kinase 33. Science. 2024 May 24;384 (6698) :885-890.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3086535-51-2]