CDD-1653

• Target :

  TGF-beta/Smad

• Related Pathways :

  Stem Cells

• Bioactivity :

  CDD-1653 is a potent BMPR2 selective inhibitor with an IC50 of 2.8 nM. It acts by inhibiting the binding of ATP to the kinase domain of BMPR2, thereby affecting the phosphorylation of the transcription factors SMAD1/5/8, which play a crucial role in the BMP signaling pathway. CDD-1653 is utilized in research related to diseases associated with the BMP signaling pathway.

• Smiles :

  O=C1N(C=2C=CC=CC2)CCN(C3=NC(=NC=C3OC)NC4=CC=CC(=C4)S(=O)(=O)N)C1

• Molecular Formula :

  C21H22N6O4S

• Molecular Weight :

  454.5

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  3034216-44-6