IRL-1620

• Description:

  IRL-1620 is a potent and selective endothelin receptor type B (ETB) agonist with a Ki of 16 pM.

• UNSPSC:

  12352209

• Hazard Statement:

  H302, H312, H332

• Target:

  Endothelin Receptor

• Type:

  Peptides

• Related Pathways:

  GPCR/G Protein

• Applications:

  Metabolism-protein/nucleotide metabolism

• Field of Research:

  Neurological Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/IRL-1620.html

• Purity:

  99.69

• Solubility:

  DMSO : 25 mg/mL (ultrasonic)

• Smiles:

  OC (C=C1) =CC=C1C[C@H] (NC ([C@H] (C (C) C) NC ([C@H] (C) NC ([C@H] (CCC (O) =O) NC ([C@H] (CCC (O) =O) NC ([C@H] (CC (O) =O) NC (CCC (O) =O) =O) =O) =O) =O) =O) =O) C (N[C@@H] (CC2=CC=CC=C2) C (N[C@@H] (C) C (N[C@@H] (CC3=CN=CN3) C (N[C@@H] (CC (C) C) C (N[C@@H] (CC (O) =O) C (N[C@@H] ([C@@H] (C) CC) C (N[C@@H] ([C@@H] (C) CC) C (N[C@H] (C (O) =O) CC4=CNC5=CC=CC=C45) =O) =O) =O) =O) =O) =O) =O) =O

• Molecular Formula:

  C86H117N17O27

• Molecular Weight:

  1820.95

• Precautions:

  H302, H312, H332

• References & Citations:

  [1]Takai M, et al. A potent and specific agonist, Suc-[Glu9, Ala11,15]-endothelin-1 (8-21), IRL 1620, for the ETB receptor. Biochem Biophys Res Commun. 1992 Apr 30;184 (2) :953-9.|[2]Briyal S, et al. Stimulation of endothelin B receptors by IRL-1620 decreases the progression of Alzheimer's disease. Neuroscience. 2015 Aug 20;301:1-11.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -80°C, 2 years; -20°C, 1 year (Powder, sealed storage, away from moisture)

• Scientific Category:

  Peptides

• Clinical Information:

  Phase 2

• Isoform:

  ETB

• CAS Number:

  142569-99-1