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M 16209

CAT: 0804-HY-101555Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101555Size:1 Each
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Description
M 16209 is an orally active aldose reductase (AR) inhibitor. M 16209 inhibits partially purified AR from various sources with IC50 values of 0.12, 0.24, 4.5, 1.2 and 9.3 μM for rat lens AR, bovine lens AR, bovine kidney AR, canine lens AR and human placental AR. M 16209 can be used for the research of metabolic disease, such as diabetes[1].
CAS Number
128851-36-5
UNSPSC
12352005
Target
Aldose Reductase
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Metabolic Disease
Smiles
O=C1NC(CN1S(=O)(C2=C(Br)C3=CC=CC=C3O2)=O)=O
Molecular Formula
C11H7BrN2O5S
Molecular Weight
359.15
References & Citations
[1]Kato K, et al. Properties of novel aldose reductase inhibitors, M16209 and M16287, in comparison with known inhibitors, ONO-2235 and sorbinil. Chem Pharm Bull (Tokyo) . 1991 Jun;39 (6) :1540-5.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 2

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