M 16209

• Description:

  M 16209 is an orally active aldose reductase (AR) inhibitor. M 16209 inhibits partially purified AR from various sources with IC50 values of 0.12, 0.24, 4.5, 1.2 and 9.3 μM for rat lens AR, bovine lens AR, bovine kidney AR, canine lens AR and human placental AR. M 16209 can be used for the research of metabolic disease, such as diabetes[1].

• UNSPSC:

  12352005

• Target:

  Aldose Reductase

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Smiles:

  O=C1NC(CN1S(=O)(C2=C(Br)C3=CC=CC=C3O2)=O)=O

• Molecular Formula:

  C11H7BrN2O5S

• Molecular Weight:

  359.15

• References & Citations:

  [1]Kato K, et al. Properties of novel aldose reductase inhibitors, M16209 and M16287, in comparison with known inhibitors, ONO-2235 and sorbinil. Chem Pharm Bull (Tokyo) . 1991 Jun;39 (6) :1540-5.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [128851-36-5]