IRL-3630

• UNSPSC Description:

  IRL-3630 (Compound 3) is an ETA/ETB antagonist (Ki: 1.9 and 1.2 nM)[1].

• Target Antigen:

  Endothelin Receptor

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/irl-3630.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=CC(C)=CC(C)=C1)N(C)[C@@H](C(N[C@@H](C(C)C)C(NS(CCCC)(=O)=O)=O)=O)CC2=CC=C(C3=CC=NO3)C=C2

• Molecular Weight:

  596.74

• References & Citations:

  [1]Sakaki J, et al. Stereoselective synthesis of a novel and bifunctional endothelin antagonist, IRL 3630. Bioorg Med Chem Lett. 1998 Aug 18;8(16):2247-52.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  173189-01-0