IRL-3630

• Description :

  IRL-3630 (Compound 3) is an ETA/ETB antagonist (Ki: 1.9 and 1.2 nM) [1].

• UNSPSC :

  12352005

• Target :

  Endothelin Receptor

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/irl-3630.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1=CC(C)=CC(C)=C1)N(C)[C@@H](C(N[C@@H](C(C)C)C(NS(CCCC)(=O)=O)=O)=O)CC2=CC=C(C3=CC=NO3)C=C2

• Molecular Formula :

  C31H40N4O6S

• Molecular Weight :

  596.74

• References & Citations :

  [1]Sakaki J, et al. Stereoselective synthesis of a novel and bifunctional endothelin antagonist, IRL 3630. Bioorg Med Chem Lett. 1998 Aug 18;8 (16) :2247-52.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [173189-01-0]