ARS-1620

• Description:

  ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.

• UNSPSC:

  12352005

• Hazard Statement:

  H302

• Target:

  Ras

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein; MAPK/ERK Pathway

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ARS-1620.html

• Concentration:

  10mM

• Purity:

  99.59

• Solubility:

  DMSO : 125 mg/mL (ultrasonic) |H2O : 11 mg/mL (ultrasonic; adjust pH to 3 with HCl)

• Smiles:

  C=CC (N1CCN (C2=C3C=C (Cl) [C@] ([C@]4=C (O) C=CC=C4F) =C (F) C3=NC=N2) CC1) =O.[S]

• Molecular Formula:

  C21H17ClF2N4O2

• Molecular Weight:

  430.84

• Precautions:

  H302

• References & Citations:

  [1]Janes MR, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018 Jan 25;172 (3) :578-589.e17.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  K-Ras

• CAS Number:

  1698055-85-4