ARS-1620

• Description :

  ARS-1620 is an atropisomeric selective KRASG12C inhibitor with desirable pharmacokinetics.

• UNSPSC :

  12352005

• Hazard Statement :

  H302

• Target :

  Ras

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/ARS-1620.html

• Concentration :

  10mM

• Purity :

  99.59

• Solubility :

  DMSO : 125 mg/mL (ultrasonic) |H2O : 11 mg/mL (ultrasonic; adjust pH to 3 with HCl)

• Smiles :

  C=CC(N1CCN(C2=C3C=C(Cl)[C@]([C@]4=C(O)C=CC=C4F)=C(F)C3=NC=N2)CC1)=O.[S]

• Molecular Formula :

  C21H17ClF2N4O2

• Molecular Weight :

  430.84

• Precautions :

  H302

• References & Citations :

  [1]Janes MR, et al. Targeting KRAS Mutant Cancers with a Covalent G12C-Specific Inhibitor. Cell. 2018 Jan 25;172 (3) :578-589.e17.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  K-Ras

• CAS Number :

  [1698055-85-4]