EU 1622-240

• Description:

  EU 1622-240 is a biased positive allosteric modulator of GluN2B, GluN2C, and GluN2D, with EC50s of 0.57, 0.82, 1.1 μM respectively. EU 1622-240 has good physicochemical properties, in vitro stability, and permeability[1].

• UNSPSC:

  12352005

• Target:

  IGluR

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Field of Research:

  Neurological Disease

• Smiles:

  C#CC1=C(C2=C(N=CN(C2=O)CC(N3CC(F)(C3)C)=O)S1)C4=CC=C(C(Br)=C4)F

• Molecular Formula:

  C20H14BrF2N3O2S

• Molecular Weight:

  478.31

• References & Citations:

  [1]Fritzemeier RG, et al. Thienopyrimidinone Derivatives as a GluN2B/C/D Biased, Positive Allosteric Modulator of the N-Methyl-d-Aspartate Receptor. J Med Chem. 2025 May 8;68 (9) :9303-9322.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [3057728-22-7]