BMS-819881

• UNSPSC Description:

  BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.

• Target Antigen:

  Cytochrome P450; MCHR1 (GPR24)

• Type:

  Reference compound

• Related Pathways:

  GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease; Endocrinology

• Assay Protocol:

  https://www.medchemexpress.com/BMS-819881.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC1=CC=C(C2=CC(N=CN(C3=CC(OC)=C(OC[C@H](O)C4CC4)C=C3)C5=O)=C5S2)C=C1

• Molecular Weight:

  468.95

• References & Citations:

  [1]Washburn WN, et al. Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate. J Med Chem. 2014 Sep 25;57(18):7509-22.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  Phase 2

• CAS Number:

  1197420-05-5