BMS-819881
CAT:
804-HY-12433
Size:
Inquire
Price:
Ask
- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
BMS-819881
- CAS Number: 1197420-05-5
- UNSPSC Description: BMS-819881 is a melaninconcentrating hormone receptor 1 (MCHR1) antagonist, which binds rat MCHR1 with a Ki of 7 nM. BMS-819881 also is selective and potent for CYP3A4 activity with an EC50 of 13 μM.
- Target Antigen: Cytochrome P450; MCHR1 (GPR24)
- Type: Reference compound
- Related Pathways: GPCR/G Protein;Metabolic Enzyme/Protease;Neuronal Signaling
- Applications: Metabolism-sugar/lipid metabolism
- Field of Research: Metabolic Disease; Endocrinology
- Assay Protocol: https://www.medchemexpress.com/BMS-819881.html
- Solubility: 10 mM in DMSO
- Smiles: ClC1=CC=C(C2=CC(N=CN(C3=CC(OC)=C(OC[C@H](O)C4CC4)C=C3)C5=O)=C5S2)C=C1
- Molecular Weight: 468.95
- References & Citations: [1]Washburn WN, et al. Identification of a nonbasic melanin hormone receptor 1 antagonist as an antiobesity clinical candidate. J Med Chem. 2014 Sep 25;57(18):7509-22.
- Shipping Conditions: Room temperature
- Clinical Information: Phase 2