BMS-986120

CAT: 0804-HY-19837-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-19837-01Size:5 mg
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Description
BMS-986120 is a first-in-class oral and reversible protease-activated receptor 4 (PAR4) antagonist, with IC50s of 9.5 nM and 2.1 nM in human and monkey blood, respectively. BMS-986120 has potent and selective antiplatelet effects[1][2].
CAS Number
[1478712-37-6]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Protease Activated Receptor (PAR)
Type
Reference compound
Related Pathways
GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/BMS-986120.html
Purity
98.22
Solubility
DMSO : 3.33 mg/mL (ultrasonic; warming; heat to 80°C)
Smiles
CC(SC(N1CCOCC1)=N2)=C2COC3=CC(OC)=CC4=C3C=C(O4)C5=CN6N=C(OC)SC6=N5
Molecular Formula
C23H23N5O5S2
Molecular Weight
513.59
Precautions
H302, H315, H319, H335
References & Citations
[1]Pancras C Wong, et al. Abstract 175: A Novel Orally-Active Small-Molecule Antagonist of the Platelet Protease-Activated Receptor-4, BMS-986120, Inhibits Arterial Thrombosis With Limited Impact on Hemostasis in Cynomolgus Monkeys. Stroke. 2018;47:A175.|[2]Wilson SJ, et al. PAR4 (Protease-Activated Receptor 4) Antagonism With BMS-986120 Inhibits Human Ex VivoThrombus Formation. Arterioscler Thromb Vasc Biol. 2018 Feb;38 (2) :448-456.|[3]Wong PC, et al. Blockade of protease-activated receptor-4 (PAR4) provides robust antithrombotic activity with low bleeding. Sci Transl Med. 2017 Jan 4;9 (371) .
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Isoform
PAR1; PAR4

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