BMS 299897

CAT: 0804-HY-50883-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-50883-01Size:5 mg
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Description
BMS 299897 is a sulfonamide γ-secretase inhibitor with an IC50 of 7 nM for Aβ production inhibition in HEK293 cells stably overexpressing amyloid precursor protein (APP) .
CAS Number
[290315-45-6]
UNSPSC
12352005
Hazard Statement
H302, H319
Target
γ-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/BMS-299897.html
Purity
99.64
Solubility
DMSO : ≥ 30 mg/mL
Smiles
FC1=CC=C(F)C(N([C@@H](C2=C(CCCC(O)=O)C=C(F)C=C2)C)S(C3=CC=C(Cl)C=C3)(=O)=O)=C1
Molecular Formula
C24H21ClF3NO4S
Molecular Weight
511.94
Precautions
H302, H319
References & Citations
[1]Meunier J, et al. The γ-secretase inhibitor 2-[ (1R) -1-[ (4-chlorophenyl) sulfonyl] (2,5-difluorophenyl) amino]ethyl-5-fluorobenzenebutanoic acid (BMS-299897) alleviates Aβ1-42 seeding and short-term memory deficits in the Aβ25-35 mouse model of Alzheimer's d|[2]Weissmiller AM, et al. A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One. 2015 Feb 24;10 (2) :e0118379.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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Alternative Products

CatalogName
M13893-01BMS-299897
A4400-5.1BMS 299897
A12444-50BMS 299897 50mg
A12444-5BMS 299897 5mg
A12444-25BMS 299897 25mg
A12444-100BMS 299897 100mg
A12444-10BMS 299897 10mg
A12444-10mM-DBMS 299897 10mM * 1mL in DMSO
B2243-5EZSolution™ BMS-299897, Sterile-filtered
217226BMS 299897, gamma-Secretase Inhibitor XXIV (4- (2- ((1R) -1- (((4-Chlorophenyl) sulfonyl) -2,5-difluoroanilino) ethyl) -5-fluorophenyl) butanoic Acid, BMS-299897, BMS 299897)

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