BMS-986143

• Description:

  BMS-986143 is an orally active, reversible BTK inhibitor with an IC50 of 0.26 nM. BMS-986143 also inhibits TEC, BLK, BMX, TXK FGR, YES1, ITK with IC50s of 3 nM, 5 nM, 7 nM, 10 nM, 15 nM,19 nM, 21 nM, respectively. BMS-986143 can be used for the research of autoimmune diseases[1].

• UNSPSC:

  12352005

• Target:

  Btk

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/bms-986143.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C (C=CC=[C@@]1[C@@]2=C (C=C (C3=C2C4=C (N3) C=C (C=C4) C (C) (O) C) C (N) =O) Cl) N5C (C=C6C (Cl) =CC=CN6C5=O) =O

• Molecular Formula:

  C31H24Cl2N4O4

• Molecular Weight:

  587.45

• References & Citations:

  [1]Anurag S Srivastava, et al. Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK. ACS Med Chem Lett. 2020 Sep 16;11 (11) :2195-2203.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  1643372-83-1