BMS-986143

BMS-986143

• CAS Number: 1643372-83-1
• UNSPSC Description: BMS-986143 is an orally active, reversible BTK inhibitor with an IC50 of 0.26 nM. BMS-986143 also inhibits TEC, BLK, BMX, TXK FGR, YES1, ITK with IC50s of 3 nM, 5 nM, 7 nM, 10 nM, 15 nM,19 nM, 21 nM, respectively. BMS-986143 can be used for the research of autoimmune diseases[1].
• Target Antigen: Btk
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/bms-986143.html
• Solubility: 10 mM in DMSO
• Smiles: CC1=C(C=CC=[C@@]1[C@@]2=C(C=C(C3=C2C4=C(N3)C=C(C=C4)C(C)(O)C)C(N)=O)Cl)N5C(C=C6C(Cl)=CC=CN6C5=O)=O
• Molecular Weight: 587.45
• References & Citations: [1]Anurag S Srivastava, et al. Driving Potency with Rotationally Stable Atropisomers: Discovery of Pyridopyrimidinedione-Carbazole Inhibitors of BTK. ACS Med Chem Lett. 2020 Sep 16;11(11):2195-2203.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported