BMS-986458

CAT: 0804-HY-172736-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-172736-01Size:5 mg
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Description
BMS-986458 is a highly selective and orally active BCL6 PROTAC degrader. BMS-986458 simultaneously co-opts cereblon (CRBN) and the BCL6 N-terminal BTB domain to catalyze proximity induced degradation of BCL6. BMS-986458 can be used for the study of B-cell Non-Hodgkin's lymphoma (Pink: Target protein ligand (HY-172740) ; Black: linker (HY-W267161) ; Blue: E3 ligase ligand (HY-W593794) ) [1].
CAS Number
[3005272-36-3]
UNSPSC
12352005
Target
BCL6; PROTACs
Related Pathways
Immunology/Inflammation; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.65
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
C[C@@H]1CN(CC[C@H]1NC2=CC=C3C(N(N=C3C4CCC(NC4=O)=O)C)=C2)C5=NC=C(C(NC6=CC7=C(N(C(C7)=O)C)C=C6)=N5)Cl
Molecular Formula
C32H34ClN9O3
Molecular Weight
628.12
References & Citations
[1]Lynda Groocock, et al. BMS-986458 a Potential First-in-Class, Highly Selective, Potent and Well Tolerated BCL6 Ligand Directed Degrader (LDD) Demonstrates Multi-Modal Anti-Tumor Efficacy for the Treatment of B-Cell Non-Hodgkin's Lymphoma. Blood. Volume 144, Supplement 1, 5 November 2024, Page 957.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Isoform
Cereblon

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