BMS-986458

• Description :

  BMS-986458 is a highly selective and orally active BCL6 PROTAC degrader. BMS-986458 simultaneously co-opts cereblon (CRBN) and the BCL6 N-terminal BTB domain to catalyze proximity induced degradation of BCL6. BMS-986458 can be used for the study of B-cell Non-Hodgkin's lymphoma (Pink: Target protein ligand (HY-172740) ; Black: linker (HY-W267161) ; Blue: E3 ligase ligand (HY-W593794) ) [1].

• UNSPSC :

  12352005

• Target :

  BCL6; PROTACs

• Related Pathways :

  Immunology/Inflammation; PROTAC

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Purity :

  99.65

• Solubility :

  DMSO : 100 mg/mL (ultrasonic)

• Smiles :

  C[C@@H]1CN(CC[C@H]1NC2=CC=C3C(N(N=C3C4CCC(NC4=O)=O)C)=C2)C5=NC=C(C(NC6=CC7=C(N(C(C7)=O)C)C=C6)=N5)Cl

• Molecular Formula :

  C32H34ClN9O3

• Molecular Weight :

  628.12

• References & Citations :

  [1]Lynda Groocock, et al. BMS-986458 a Potential First-in-Class, Highly Selective, Potent and Well Tolerated BCL6 Ligand Directed Degrader (LDD) Demonstrates Multi-Modal Anti-Tumor Efficacy for the Treatment of B-Cell Non-Hodgkin's Lymphoma. Blood. Volume 144, Supplement 1, 5 November 2024, Page 957.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  Phase 2

• Isoform :

  Cereblon

• CAS Number :

  [3005272-36-3]