Duocarmycin MB

• Description:

  Duocarmycin MB is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-agent resistant cell lines.

• UNSPSC:

  12352203

• Target:

  ADC Payload; DNA Alkylator/Crosslinker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/duocarmycin-mb.html

• Solubility:

  10 mM in DMSO

• Smiles:

  ClC[C@H]1C2=C (C=C (O) C3=CC=CC=C23) N (C (C4=CC5=CC=C (NC (OC (C) (C) C) =O) C=C5N4) =O) C1

• Molecular Formula:

  C27H26ClN3O4

• Molecular Weight:

  491.97

• References & Citations:

  [1]Searcey M. Duocarmycins--natures prodrugs? Curr Pharm Des. 2002;8 (15) :1375-89.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Duocarmycins

• CAS Number:

  1613286-58-0