Duocarmycin MB

• Description :

  Duocarmycin MB is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MB can be used against multi-agent resistant cell lines.

• UNSPSC :

  12352203

• Target :

  ADC Payload; DNA Alkylator/Crosslinker

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/duocarmycin-mb.html

• Solubility :

  10 mM in DMSO

• Smiles :

  ClC[C@H]1C2=C(C=C(O)C3=CC=CC=C23)N(C(C4=CC5=CC=C(NC(OC(C)(C)C)=O)C=C5N4)=O)C1

• Molecular Formula :

  C27H26ClN3O4

• Molecular Weight :

  491.97

• References & Citations :

  [1]Searcey M. Duocarmycins--natures prodrugs? Curr Pharm Des. 2002;8 (15) :1375-89.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Duocarmycins

• CAS Number :

  [1613286-58-0]