Seco-Duocarmycin TM

CAT: 0804-HY-130083Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-130083Size:1 Each
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Description
Seco-Duocarmycin TM is a DNA alkylator agent belonging to Duocarmycins family that inhibits DNA synthesis. Seco-Duocarmycin TM is a cytotoxic agent, used as the cytotoxic component in antibody-drug conjugates (ADC) [1].
CAS Number
[236102-87-7]
UNSPSC
12352203
Target
ADC Payload; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/seco-duocarmycin-tm.html
Solubility
10 mM in DMSO
Smiles
OC[C@H]1C2=C(C=CC=C3)C3=C(O)C=C2N(C(C4=CC(C=C(OC)C(OC)=C5OC)=C5N4)=O)C1
Molecular Formula
C25H24N2O6
Molecular Weight
448.47
References & Citations
[1]Gieseg MA, et al. Comparison of the patterns of DNA alkylation by phenol and amino seco-CBI-TMI compounds: use of a PCR method for the facile preparation of single end-labelled double-stranded DNA. Anticancer Drug Des. 1999 Feb;14 (1) :77-84.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Duocarmycins

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