Duocarmycin SA

• Description:

  Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2].

• UNSPSC:

  12352203

• Hazard Statement:

  H302, H340, H350, H360

• Target:

  ADC Payload; Antibiotic; Apoptosis; DNA Alkylator/Crosslinker; Necroptosis

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/duocarmycin-sa.html

• Purity:

  99.89

• Solubility:

  DMSO : 50 mg/mL

• Smiles:

  O=C(C(N1)=CC([C@@]23[C@@](C3)([H])CN(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)C2=C6)=C1C6=O)OC

• Molecular Formula:

  C25H23N3O7

• Molecular Weight:

  477.47

• Precautions:

  H302, H340, H350, H360

• References & Citations:

  [1]MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19 (24) :6962-5.|[2]Boyle KE, et.al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1;28 (16) :2688-2692. |[3]Ichimura M, et.al. Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp. J Antibiot (Tokyo) . 1990 Aug;43 (8) :1037-8.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, stored under nitrogen)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Duocarmycins

• CAS Number:

  [130288-24-3]