Duocarmycin SA

CAT: 0804-HY-12456-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0804-HY-12456-01Size:1 mg
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Description
Duocarmycin SA is an orally active antitumor antibiotic with an IC50 of 10 pM[1]. Duocarmycin SA is an extremely potent cytotoxic agent capable of inducing a sequence-selective alkylation of duplex DNA. Duocarmycin SA demonstrates synergistic cytotoxicity against glioblastoma multiforme (GBM) cells treated with proton radiation in vitro[2].
CAS Number
[130288-24-3]
UNSPSC
12352203
Hazard Statement
H302, H340, H350, H360
Target
ADC Payload; Antibiotic; Apoptosis; DNA Alkylator/Crosslinker; Necroptosis
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/duocarmycin-sa.html
Purity
99.89
Solubility
DMSO : 50 mg/mL
Smiles
O=C(C(N1)=CC([C@@]23[C@@](C3)([H])CN(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)C2=C6)=C1C6=O)OC
Molecular Formula
C25H23N3O7
Molecular Weight
477.47
Precautions
H302, H340, H350, H360
References & Citations
[1]MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19 (24) :6962-5.|[2]Boyle KE, et.al. Duocarmycin SA, a potent antitumor antibiotic, sensitizes glioblastoma cells to proton radiation. Bioorg Med Chem Lett. 2018 Sep 1;28 (16) :2688-2692. |[3]Ichimura M, et.al. Duocarmycin SA, a new antitumor antibiotic from Streptomyces sp. J Antibiot (Tokyo) . 1990 Aug;43 (8) :1037-8.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Duocarmycins

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