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Seco-Duocarmycin SA

CAT: 0804-HY-129356Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-129356Size:1 Each
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Description
Seco-Duocarmycin SA is a DNA alkylator. Seco-Duocarmycin SA is an antitumor antibiotic (IC50 = 10 pM) . Seco-Duocarmycin SA can induce a concentration-dependent increase in apoptotic cell death. Seco-Duocarmycin SA can lead to significant cell cycle arrest in S and G2/M phases. Seco-Duocarmycin SA acts as an ADC cytotoxin for antibody-drug conjugates[1][2][3].
CAS Number
144667-38-9
UNSPSC
12352203
Target
ADC Payload; Antibiotic; Apoptosis; DNA Alkylator/Crosslinker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/seco-duocarmycin-sa.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC2=C3C(N(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)CC3CCl)=CC(O)=C2N1)OC
Molecular Formula
C25H24ClN3O7
Molecular Weight
513.93
References & Citations
[1]Lutz F. Tietze, et al. A Concise and Efficient Synthesis of seco-Duocarmycin SA. European Journal of Organic Chemistry 2003 (3), 562-566.|[2]Morcos, A., et al., (2025) . Seco-Duocarmycin SA in Aggressive Glioblastoma Cell Lines. International journal of molecular sciences, 26 (6), 2766.|[3]Tichenor MS, et al. Systematic exploration of the structural features of yatakemycin impacting DNA alkylation and biological activity. J Am Chem Soc. 2007 Sep 5;129 (35) :10858-69.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Duocarmycins

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