Duocarmycin A

Duocarmycin A

• CAS Number: 118292-34-5
• UNSPSC Description: Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].
• Target Antigen: ADC Cytotoxin; Antibiotic; Apoptosis; Caspase
• Type: ADC Related
• Related Pathways: Antibody-drug Conjugate/ADC Related;Anti-infection;Apoptosis
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/duocarmycin-a.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@@](N1)(C)C(C([C@@]23[C@@](C3)([H])CN(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)C2=C6)=C1C6=O)=O)OC
• Molecular Weight: 507.49
• References & Citations: [1]Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39(5):988-96.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported