Duocarmycin A

CAT: 0804-HY-12455Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-12455Size:1 Each
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Description
Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].
CAS Number
[118292-34-5]
UNSPSC
12352203
Target
ADC Payload; Antibiotic; Apoptosis; Caspase
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/duocarmycin-a.html
Solubility
10 mM in DMSO
Smiles
O=C([C@@](N1)(C)C(C([C@@]23[C@@](C3)([H])CN(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)C2=C6)=C1C6=O)=O)OC
Molecular Formula
C26H25N3O8
Molecular Weight
507.49
References & Citations
[1]Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39 (5) :988-96.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Caspase 3; Caspase 9; Duocarmycins

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