Duocarmycin A

• Description :

  Duocarmycin A, which is one of well-known antitumor antibiotics, is a DNA alkylator and efficiently alkylates adenine N3 at the 3′ end of AT-rich sequences in the DNA. Duocarmycin A, as a chemotherapeutic agent, results HLC-2 cells typically apoptotic changes, including chromatin condensation, sub-G1 accumulation in DNA histogram pattern, and decrease in procaspase-3 and 9 levels[1].

• UNSPSC :

  12352203

• Target :

  ADC Payload; Antibiotic; Apoptosis; Caspase

• Type :

  ADC Related

• Related Pathways :

  Antibody-drug Conjugate/ADC Related; Anti-infection; Apoptosis

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/duocarmycin-a.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C([C@@](N1)(C)C(C([C@@]23[C@@](C3)([H])CN(C(C(N4)=CC5=C4C(OC)=C(OC)C(OC)=C5)=O)C2=C6)=C1C6=O)=O)OC

• Molecular Formula :

  C26H25N3O8

• Molecular Weight :

  507.49

• References & Citations :

  [1]Hirota M, et al. Distamycin A enhances the cytotoxicity of duocarmycin A and suppresses duocarmycin A-induced apoptosis in human lung carcinoma cells. Int J Biochem Cell Biol. 2007;39 (5) :988-96.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  ADC Related

• Clinical Information :

  No Development Reported

• Isoform :

  Caspase 3; Caspase 9; Duocarmycins

• CAS Number :

  [118292-34-5]