Duocarmycin MA

• Description:

  Duocarmycin MA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-agent resistant cell lines.

• UNSPSC:

  12352203

• Target:

  ADC Payload; DNA Alkylator/Crosslinker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/duocarmycin-ma.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C (OC (C) (C) C) NC1=CC=C (C (NC2=CC3=C (C=C2) C=C (C (N4C[C@@H] (CCl) C5=C4C=C (O) C6=CC=CC=C56) =O) N3) =O) C=C1

• Molecular Formula:

  C34H31ClN4O5

• Molecular Weight:

  611.09

• References & Citations:

  [1]Searcey M. Duocarmycins--natures prodrugs? Curr Pharm Des. 2002;8 (15) :1375-89.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Duocarmycins

• CAS Number:

  1613286-57-9