Duocarmycin MA

• Description:

  Duocarmycin MA is an antibody agent conjugates (ADCs) toxin. Duocarmycin is a DNA alkylating agent that binds in the minor groove. Duocarmycin MA can be used against multi-agent resistant cell lines.

• UNSPSC:

  12352203

• Target:

  ADC Payload; DNA Alkylator/Crosslinker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/duocarmycin-ma.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(OC(C)(C)C)NC1=CC=C(C(NC2=CC3=C(C=C2)C=C(C(N4C[C@@H](CCl)C5=C4C=C(O)C6=CC=CC=C56)=O)N3)=O)C=C1

• Molecular Formula:

  C34H31ClN4O5

• Molecular Weight:

  611.09

• References & Citations:

  [1]Searcey M. Duocarmycins--natures prodrugs? Curr Pharm Des. 2002;8 (15) :1375-89.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Duocarmycins

• CAS Number:

  [1613286-57-9]