Duocarmycin TM

• Description:

  Duocarmycin TM (CBI-TMI) is a potent antitumor antibiotic. Duocarmycin TM induces a sequence-selective alkylation of duplex DNA.

• Product Name Alternative:

  CBI-TMI

• UNSPSC:

  12352203

• Target:

  ADC Payload; Antibiotic; DNA Alkylator/Crosslinker

• Type:

  ADC Related

• Related Pathways:

  Antibody-drug Conjugate/ADC Related; Anti-infection; Cell Cycle/DNA Damage

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/Duocarmycin_TM.html

• Purity:

  99.82

• Solubility:

  DMSO : ≥ 50 mg/mL

• Smiles:

  ClC[C@H]1C2=C(C=CC=C3)C3=C(O)C=C2N(C(C4=CC(C=C(OC)C(OC)=C5OC)=C5N4)=O)C1

• Molecular Formula:

  C25H23ClN2O5

• Molecular Weight:

  466.91

• References & Citations:

  [1]Zhang D, et, al. Immolation of p-Aminobenzyl Ether Linker and Payload Potency and Stability Determine the Cell-Killing Activity of Antibody-Drug Conjugates with Phenol-Containing Payloads. Bioconjug Chem. 2018 Feb 21;29 (2) :267-274.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  ADC Related

• Clinical Information:

  No Development Reported

• Isoform:

  Duocarmycins

• CAS Number:

  [157922-77-5]