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Win 58237

CAT: 0804-HY-101661Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-101661Size:1 Each
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Description
Win 58237 is a cyclic nucleotide phosphodiesterase (PDE) inhibitor, with Ki of 170 nM for PDE V, possessing vasorelaxant activity.
CAS Number
158001-76-4
UNSPSC
12352005
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/Win_58237.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(N(C3CCCC3)N=C2C)NC(C4=CC=NC=C4)=N1
Molecular Formula
C16H17N5O
Molecular Weight
295.34
References & Citations
[1]Silver PJ, et al. Cyclic GMP potentiation by WIN 58237, a novel cyclic nucleotide phosphodiesterase inhibitor. J Pharmacol Exp Ther. 1994 Dec;271 (3) :1143-9.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

1-cyclopentyl-3-methyl-6-pyridin-4-yl-5H-pyrazolo[5,4-d]pyrimidin-4-one
CAS Number158001-76-4
PubChem CID135494251
IUPAC Name1-cyclopentyl-3-methyl-6-pyridin-4-yl-5H-pyrazolo[5,4-d]pyrimidin-4-one
Molecular FormulaC16H17N5O
Molecular Weight295.34
XLogP1.5
Topological Polar Surface Area72.2
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Heavy Atom Count22
Formal Charge0
Complexity467
SMILES
CC1=NN(C2=C1C(=O)NC(=N2)C3=CC=NC=C3)C4CCCC4
InChI
InChI=1S/C16H17N5O/c1-10-13-15(21(20-10)12-4-2-3-5-12)18-14(19-16(13)22)11-6-8-17-9-7-11/h6-9,12H,2-5H2,1H3,(H,18,19,22)
InChIKey
GODZWYONGRENHA-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 1-cyclopentyl-3-methyl-6-pyridin-4-yl-5H-pyrazolo[5,4-d]pyrimidin-4-one
CAS: 158001-76-4
CID: 135494251
Formula: C16H17N5O
MW: 295.34
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight295.34
XLogP31.5
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count4
Rotatable Bond Count2
Exact Mass295.14331018
Monoisotopic Mass295.14331018
Topological Polar Surface Area72.2 Ų
Heavy Atom Count22
Formal Charge0
Complexity467
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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