Win 18446

CAT: 0804-HY-W011094-01Size: 50 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W011094-01Size:50 mg
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Description
Win 18446 is an orally active testes-specific enzyme ALDH1a2 inhibitor, with an IC50 of 0.3 μM. Win 18446 reversibly inhibits spermatogenesis in many species and inhibits Retinoic acid (HY-14649) biosynthesis from Retinol (HY-B1342) within the testes[1][2].
CAS Number
[1477-57-2]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Aldehyde Dehydrogenase (ALDH)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Endocrinology
Assay Protocol
https://www.medchemexpress.com/win-18446.html
Purity
98.94
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C(NCCCCCCCCNC(C(Cl)Cl)=O)C(Cl)Cl
Molecular Formula
C12H20Cl4N2O2
Molecular Weight
366.11
Precautions
H302, H315, H319, H335
References & Citations
[1]John K Amory, et al. Suppression of spermatogenesis by bisdichloroacetyldiamines is mediated by inhibition of testicular retinoic acid biosynthesis. J Androl. Jan-Feb 2011;32 (1) :111-9.|[2]Cathryn A Hogarth, et al. Suppression of Stra8 expression in the mouse gonad by WIN 18,446. Biol Reprod. 2011 May;84 (5) :957-65.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, stored under nitrogen)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ALDH1

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