WIN 62577

• Description :

  WIN 62577 is a species-selective tachykinin NK1 receptor antagonist. WIN 62577 is also an allosteric enhancer with micromolar potency at M3 receptors. WIN 62577 exhibits potent antiviral activity against SARS-CoV-2[1][2][3].

• UNSPSC :

  12352005

• Target :

  MAChR; Neurokinin Receptor; SARS-CoV

• Related Pathways :

  Anti-infection; GPCR/G Protein; Neuronal Signaling

• Field of Research :

  Infection; Neurological Disease

• Smiles :

  C[C@@]12[C@]3([H])[C@](CCC1=CC4=NC5=NC6=CC=CC=C6N5C=C4C2)([H])[C@@]7([H])[C@](CC3)([C@](O)(CC7)C#C)C

• Molecular Formula :

  C29H31N3O

• Molecular Weight :

  437.58

• References & Citations :

  [1]Briejer MR, et, al. Substance P-induced contractions of the guinea-pig proximal colon through stimulation of post-junctional tachykinin NK1 receptors. Eur J Pharmacol. 1993 Nov 30;250 (1) :181-3.|[2]Lazareno S, et, al. Progress toward a high-affinity allosteric enhancer at muscarinic M1 receptors. J Mol Neurosci. 2003;20 (3) :363-7. |[3]Singh A, et, al. Structural and Mechanistic Insights into the Main Protease (Mpro) Dimer Interface Destabilization Inhibitor: Unveiling New Therapeutic Avenues against SARS-CoV-2. Biochemistry. 2025 Apr 1;64 (7) :1589-1605.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [138091-43-7]