Win-62005

CAT: 0804-HY-U00136Size: 1 EachDry Ice: NoHazardous: No

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Description

Win-62005 is a cyclic AMP phosphodiesterase III (PDE III) inhibitor with Kis of 25 and 26 nM for rat heart and canine aorta, respectively.

CAS Number

152633-54-0

UNSPSC

12352005

Target

Phosphodiesterase (PDE)

Type

Reference compound

Related Pathways

Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/Win-62005.html

Solubility

10 mM in DMSO

Smiles

O=C1NC2=NC(C)=C(C3=CC=NC=C3)C=C2N1

Molecular Formula

C12H10N4O

Molecular Weight

226.23

References & Citations

[1]Dundore RL, et al. Species-dependent pharmacodynamic effects of the selective low Km cyclic AMP phosphodiesterase III inhibitors WIN 58993 and WIN 62005. J Cardiovasc Pharmacol. 1995 Jan;25 (1) :14-21.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

Win 62005

inhibits cAMP phosphodiesterase III; structure in first source

CAS Number	152633-54-0
PubChem CID	5492217
IUPAC Name	5-methyl-6-pyridin-4-yl-1,3-dihydroimidazo[4,5-b]pyridin-2-one
Molecular Formula	C12H10N4O
Molecular Weight	226.23
XLogP	0.8
Topological Polar Surface Area	66.9
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Heavy Atom Count	17
Formal Charge	0
Complexity	303

SMILES

CC1=NC2=C(C=C1C3=CC=NC=C3)NC(=O)N2

InChI

InChI=1S/C12H10N4O/c1-7-9(8-2-4-13-5-3-8)6-10-11(14-7)16-12(17)15-10/h2-6H,1H3,(H2,14,15,16,17)

InChIKey

MQMTXZJPAGLGFF-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 152633-54-0

CID: 5492217

Formula: C12H10N4O

MW: 226.23

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	226.23
XLogP3	0.8
Hydrogen Bond Donor Count	2
Hydrogen Bond Acceptor Count	3
Rotatable Bond Count	1
Exact Mass	226.08546096
Monoisotopic Mass	226.08546096
Topological Polar Surface Area	66.9 Å²
Heavy Atom Count	17
Formal Charge	0
Complexity	303
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

Related Products

Catalog	Name
HY-106296-01	WIN 54954
HY-171460	Win 45164
HY-101368	WIN 64338
HY-W100186-01	Win 47338
HY-W011094-01	Win 18446
HY-101661	Win 58237
HY-105346-01	WIN 51708
HY-169501	WIN 62577
HY-105418	WIN-63291
HY-P10588	WIN 66306

Alternative Products

Catalog	Name
MBS5767857	Win-62005
RGA59963-01	WIN 54461
T125767-01	WIN 68577
T61652-01	WIN 54954
MBS3602038-01	WIN-18446
TRC-W498820-10MG	Win 18446
MBS5814438	WIN 66306
MBS5791244	WIN-64821
MBS5784616	WIN-68056
T206477-01	Win 45164

Win-62005

Chemical Information

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