Win 47338

• Description :

  Win 47338 (compound 14) is a control compound of inhibitors of the mitotic kinase monopolar spindle MPS1 and Aurora kinases (AurA/AurB) (Ki>100 μM) [1].

• CAS Number :

  [80047-24-1]

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Aurora Kinase

• Related Pathways :

  Cell Cycle/DNA Damage; Epigenetics

• Field of Research :

  Others

• Smiles :

  O=C(C1=CC(C2=CC=NC=C2)=C(C)NC1=O)N

• Molecular Formula :

  C12H11N3O2

• Molecular Weight :

  229.23

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

• References & Citations :

  [1]Fearon D, et al. Synthesis and profiling of a 3-aminopyridin-2-one-based kinase targeted fragment library: Identification of 3-amino-5- (pyridin-4-yl) pyridin-2 (1H) -one scaffold for monopolar spindle 1 (MPS1) and Aurora kinases inhibition. Bioorg Med Chem. 2018 Jul 15;26 (11) :3021-3029.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported