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Garcinone C (Standard)

CAT: 0804-HY-N6954RSize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-N6954RSize:1 Each
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Description
Garcinone C (Standard) is the analytical standard of Garcinone C. This product is intended for research and analytical applications. Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active[1][2].
CAS Number
76996-27-5
UNSPSC
12352005
Target
ATM/ATR; CDK; Hedgehog; Reference Standards; STAT
Type
Reference Standards
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; Others; PI3K/Akt/mTOR; Stem Cell/Wnt
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/garcinone-c-standard.html
Smiles
CC(C)(O)CCC1=C(O)C(O)=CC(OC2=CC(O)=C(C/C=C(C)/C)C(O)=C23)=C1C3=O
Molecular Formula
C23H26O7
Molecular Weight
414.45
References & Citations
[1]Xia Y, et al. Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E BP1 in nasopharyngeal carcinoma cells. Oncol Rep. 2018 Mar;39 (3) :1485-1493.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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