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Garcinone C

CAT: 0804-HY-N6954Size: 5 mgDry Ice: NoHazardous: No
CAT#: HY-N6954Size: 5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Garcinone C, a xanthone derivative, is a natural compound extracted from Garcinia oblongifolia that is used as an anti-inflammatory, astringency and granulation-promoting medicine, and has potential cytotoxic effects on certain cancers. Garcinone C stimulates the expression levels of ATR and 4E-BP1, arrests the cell cycle, inhibits cell viability of the human Nasopharyngeal carcinoma (NPC) cell lines CNE1, CNE2, HK1 and HONE1 in a time‑ and dose‑dependent manner through inhibition of Hedgehog signaling pathway. Garcinone C is orally active[1][2].
CAS Number
[76996-27-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
ATM/ATR; CDK; Hedgehog; STAT
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; JAK/STAT Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/garcinone-c.html
Purity
99.51
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
CC(C)(O)CCC1=C(O)C(O)=CC(OC2=CC(O)=C(C/C=C(C)/C)C(O)=C23)=C1C3=O
Molecular Formula
C23H26O7
Molecular Weight
414.45
Precautions
H302, H315, H319, H335
References & Citations
[1]Xia Y, et al. Garcinone C exerts antitumor activity by modulating the expression of ATR/Stat3/4E BP1 in nasopharyngeal carcinoma cells. Oncol Rep. 2018 Mar;39 (3) :1485-1493.|[2]Chen J, et al., Garcinone C suppresses colon tumorigenesis through the Gli1-dependent hedgehog signaling pathway. Phytomedicine. 2020 Dec;79:153334.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
ATR; CDK7; STAT3

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