C-021 (Standard)

• Description :

  C-021 (Standard) is the analytical standard of C-021. This product is intended for research and analytical applications. C-021 is a potent CC chemokine receptor-4 (CCR4) antagonist. C-021 potently inhibits functional chemotaxis in human and mouse with IC50s of 140 nM and 39 nM, respectively. C-021 effectively prevents human CCL22-derived [35S]GTPγS from binding to the receptor with an IC50 of 18 nM[1].

• UNSPSC :

  12352005

• Target :

  CCR; Reference Standards

• Related Pathways :

  GPCR/G Protein; Immunology/Inflammation; Others

• Field of Research :

  Inflammation/Immunology

• Smiles :

  COC1=CC2=NC(N3CCC(N4CCCCC4)CC3)=NC(NC5CCCCCC5)=C2C=C1OC

• Molecular Formula :

  C27H41N5O2

• Molecular Weight :

  467.65

• References & Citations :

  [1]Yokoyama K, et al. Potent and orally bioavailable CCR4 antagonists: Synthesis and structure-activity relationship study of 2-aminoquinazolines. Bioorg Med Chem. 2009 Jan 1;17 (1) :64-73.|[2]Matthew McMillin, et al. Neuronal CCL2 is upregulated during hepatic encephalopathy and contributes to microglia activation and neurological decline. J Neuroinflammation. 2014 Jul 10;11:121.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference Standards

• CAS Number :

  [864289-85-0]