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Garcinol (Standard)

CAT: 0804-HY-107569RSize: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-107569RSize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Garcinol (Standard) is the analytical standard of Garcinol. This product is intended for research and analytical applications. Garcinol, a polyisoprenylated benzophenone harvested from Garcinia indica, exerts anti-cholinesterase properties towards acetyl cholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50s of 0.66 μM and 7.39 μM, respectively[1]. Garcinol also inhibits histone acetyltransferases (HATs, IC50= 7 μM) and p300/CPB-associated factor (PCAF, IC50 = 5 μM) . Garcinol has anti-inflammatory and anti-cancer activity[2].
CAS Number
[78824-30-3]
UNSPSC
12352100
Target
Apoptosis; Cholinesterase (ChE) ; Endogenous Metabolite; Histone Acetyltransferase; Reference Standards
Related Pathways
Apoptosis; Epigenetics; Metabolic Enzyme/Protease; Neuronal Signaling; Others
Field of Research
Cancer; Inflammation/Immunology
Smiles
C/C(C)=C\C[C@@H](C[C@]12C([C@](C(C)([C@@H](C2)C/C=C(C)\C)C)(C/C=C(C)\C)C(C(C(C3=CC(O)=C(C=C3)O)=O)=C1O)=O)=O)C(C)=C
Molecular Formula
C38H50O6
Molecular Weight
602.80
References & Citations
[1]Lenta BN, et al. Leishmanicidal and cholinesterase inhibiting activities of phenolic compounds from Allanblackia monticola and Symphonia globulifera. Molecules. 2007 Jul 20;12 (8) :1548-57.|[2]Ciochina R, et al. Polycyclic polyprenylated acylphloroglucinols. Chem Rev. 2006 Sep;106 (9) :3963-86.|[3]Li F, et al. Garcinol, a polyisoprenylated benzophenone modulates multiple proinflammatory signalingcascades leading to the suppression of growth and survival of head and neck carcinoma. Cancer Prev Res (Phila) . 2013 Aug;6 (8) :843-54.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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