Garcinone D

• UNSPSC Description:

  Garcinone D, a natural xanthone from mangosteen, promotes the proliferation of C17.2 neural stem cell. Garcinone D increases the protein levels of phosphorylated signal transducer and activator of transcription 3 (p-STAT3), Cyclin D1 and nuclear factor erythroid 2-related factor (Nrf2), heme oxygenase-1 (HO-1) in concentration- and time- dependent manners[1].

• Target Antigen:

  Keap1-Nrf2; Reactive Oxygen Species; STAT

• Type:

  Natural Products

• Related Pathways:

  Immunology/Inflammation;JAK/STAT Signaling;Metabolic Enzyme/Protease;NF-κB;Stem Cell/Wnt

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/garcinone-d.html

• Purity:

  99.88

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  CC(C)(O)CCC1=C(OC)C(O)=CC(OC2=CC(O)=C(C/C=C(C)/C)C(O)=C23)=C1C3=O

• Molecular Weight:

  428.47

• References & Citations:

  [1]Yang X, et al. Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. Neurosci Lett. 2016 Jul 28;626:6-12.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, protect from light)

• Clinical Information:

  No Development Reported

• CAS Number:

  107390-08-9