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Garcinone D

CAT: 0804-HY-N6953-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-N6953-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Garcinone D is an activator of the STAT3/Cyclin D1 and Nrf2/HO-1 pathways, and an inhibitor of CDK2/CyclinE1 (IC50 for CDK2/CyclinE1 is 28.23 μM) . Garcinone D promotes neural stem cell proliferation by activating STAT3 phosphorylation and Cyclin D1 expression and enhancing the Nrf2/HO-1 signaling pathway. In addition, Garcinone D blocks the tumor cell cycle by inhibiting CDK2/CyclinE1. Garcinone D can promote the proliferation of C17.2 neural stem cells and inhibit prostate and breast cancer[1][2].
CAS Number
107390-08-9
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Keap1-Nrf2; Reactive Oxygen Species (ROS) ; STAT
Type
Natural Products
Related Pathways
Immunology/Inflammation; JAK/STAT Signaling; Metabolic Enzyme/Protease; NF-κB; Stem Cell/Wnt
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/garcinone-d.html
Purity
99.88
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)(O)CCC1=C(OC)C(O)=CC(OC2=CC(O)=C(C/C=C(C)/C)C(O)=C23)=C1C3=O
Molecular Formula
C24H28O7
Molecular Weight
428.47
Precautions
H302, H315, H319, H335
References & Citations
[1]Yang X, et al. Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. Neurosci Lett. 2016 Jul 28;626:6-12.|[2]Nauman MC, et al. Inhibition of CDK2/CyclinE1 by xanthones from the mangosteen (Garcinia mangostana) : a structure-activity relationship study. Nat Prod Res. 2021 Dec;35 (23) :5429-5433.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Isoform
STAT3

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