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PDE1-IN-9

CAT: 0804-HY-169402-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-169402-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDE1-IN-9 (Compound 7a) is a selective inhibitor for phosphodiesterase 1 (PDE1), that inhibits PDE1C with an IC50 of 11 nM. PDE1-IN-9 reduces mRNA expression of IL-1β, IL-6, TNF-α and iNOS, inhibits the production of nitric oxide (NO) and reactive oxygen species (ROS) . PDE1-IN-9 exhibits good metabolic stability in rat liver microsomes[1].
CAS Number
2982945-41-3
UNSPSC
12352203
Target
Interleukin Related; NO Synthase; Phosphodiesterase (PDE) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde1-in-9.html
Smiles
N#CC1=C(C2CCCC2)C3=C(C=C(NCC4CCOCC4)C=C3)N(CC5=CC=CC=C5)C1=O
Molecular Formula
C28H31N3O2
Molecular Weight
441.56
References & Citations
[1]Zhou Q, et al., Design, synthesis, and evaluation of quinolin-2 (1H) -ones as PDE1 inhibitors for the treatment of inflammatory bowel disease. Bioorg Chem. 2024 Nov 19;154:107979.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
IL-1; IL-6; PDE1

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