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PDE1-IN-4

CAT: 0804-HY-147946Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147946Size:1 Each
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Description
PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate) . PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research[1].
CAS Number
3031349-98-8
UNSPSC
12352005
Target
Calcium Channel; Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pde1-in-4.html
Solubility
10 mM in DMSO
Smiles
CC1=C(C(C2=CC3=C(C=C2)N(N=C3)C)C(C(O[C@@H](C4=CC=CC=C4)C)=O)=C(N1)C)C(O[C@@H](C5=CC=CC=C5)C)=O
Molecular Formula
C33H33N3O4
Molecular Weight
535.63
References & Citations
[1]Huang MX, et al. Structural Modifications of Nimodipine Lead to Novel PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects. J Med Chem. 2022 Jun 23;65 (12) :8444-8455.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PDE1; PDE10; PDE2; PDE3; PDE4; PDE5; PDE9

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