PDE1-IN-4

CAT:
804-HY-147946
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  • Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
  • Dry Ice Shipment: No
PDE1-IN-4 - image 1

PDE1-IN-4

  • UNSPSC Description:

    PDE1-IN-4 (compound 2g) is a potent and selective PDE1 (phosphodiesterase-1) inhibitor, with IC50 values of 10, 145, and 354 nM for PDE1C, PDE1A, and PDE1B, respectively. PDE1-IN-4 inhibits myofibroblast differentiation of human lung fibroblasts induced by TGF-β1. PDE1-IN-4 shows anti-fibrosis effects through the regulation of cAMP (3′,5′-cyclic adenosine monophosphate) and cGMP (3′,5′-cyclic guanosine monophosphate). PDE1-IN-4 can be used for idiopathic pulmonary fibrosis (IPF) research[1].
  • Target Antigen:

    Calcium Channel; Phosphodiesterase (PDE)
  • Type:

    Reference compound
  • Related Pathways:

    Membrane Transporter/Ion Channel;Metabolic Enzyme/Protease;Neuronal Signaling
  • Applications:

    COVID-19-immunoregulation
  • Field of Research:

    Inflammation/Immunology
  • Assay Protocol:

    https://www.medchemexpress.com/pde1-in-4.html
  • Solubility:

    10 mM in DMSO
  • Smiles:

    CC1=C(C(C2=CC3=C(C=C2)N(N=C3)C)C(C(O[C@@H](C4=CC=CC=C4)C)=O)=C(N1)C)C(O[C@@H](C5=CC=CC=C5)C)=O
  • Molecular Weight:

    535.63
  • References & Citations:

    [1]Huang MX, et al. Structural Modifications of Nimodipine Lead to Novel PDE1 Inhibitors with Anti-pulmonary Fibrosis Effects. J Med Chem. 2022 Jun 23;65(12):8444-8455.
  • Shipping Conditions:

    Room temperature
  • Clinical Information:

    No Development Reported
  • CAS Number:

    3031349-98-8