PDE1-IN-5

PDE1-IN-5

• CAS Number: 2982945-34-4
• UNSPSC Description: PDE1-IN-5 (Compound 10c) is a selective PDE1C inhibitor (IC50: 15 nM). PDE1-IN-5 has anti- inflammatory activity, and inhibits expression of iNOS, TNF-α, IL-1α, IL-1β, and IL-6 induced by LPS. PDE1-IN-5 has anti-inflammatory bowel disease (IBD) effects in the dextran sodium sulfate (DSS)-Induced colitis mice model. PDE1-IN-5 can be used for research of IBD[1].
• Target Antigen: Phosphodiesterase (PDE)
• Type: Reference compound
• Related Pathways: Metabolic Enzyme/Protease
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pde1-in-5.html
• Solubility: 10 mM in DMSO
• Smiles: O=C1C(C#N)=C(C2=CC=C(C=C2N1CC3CCCC3)NCC4=CC=C(C=N4)F)C5CCCC5
• Molecular Weight: 444.54
• References & Citations: [1]Zhang B, et al. Identification of Novel Quinolin-2(1H)-ones as Phosphodiesterase 1 Inhibitors for the Treatment of Inflammatory Bowel Disease. J Med Chem. 2023 Sep 14;66(17):12468-12478.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported