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PDE1-IN-6

CAT: 0804-HY-163406Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-163406Size:1 Each
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Description
PDE1-IN-6 (compound 6c) is a selectivity PDE1 inhibitor with the IC50 of 7.5 nM. PDE1-IN-6 significantly inhibits the proliferation and induced cell apoptosis in Acute myelogenous leukemia cells[1].
CAS Number
2877017-16-6
UNSPSC
12352005
Target
Apoptosis; Phosphatase
Type
Reference compound
Related Pathways
Apoptosis; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pde1-in-6.html
Solubility
10 mM in DMSO
Smiles
CC(C)(N1N=CC2=C1N=C(N(C2=O)CC3=CC=CC(F)=C3)NCCNC4=CC=C(C=C4)F)C
Molecular Formula
C24H26F2N6O
Molecular Weight
452.50
References & Citations
[1]Le ML, et al. Discovery of novel selective phosphodiesterase‑1 inhibitors for the treatment of acute myelogenous leukemia. Bioorg Chem. 2024;144:107114.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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