PDE1-IN-9

CAT: 0931-MF-0112231-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0112231-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2982945-41-3
Target
NO Synthase|||PDE
Related Pathways
Immunology/Inflammation|||Metabolism
Bioactivity
PDE1-IN-9 (Compound 7a) is a selective inhibitor of phosphodiesterase 1 (PDE1), targeting PDE1C with an IC50 value of 11 nM. It effectively reduces the mRNA expression of IL-1?, IL-6, TNF-?, and iNOS, while also inhibiting the production of nitric oxide (NO) and reactive oxygen species (ROS) . Additionally, PDE1-IN-9 demonstrates good metabolic stability in rat liver microsomes.
Smiles
N#CC=1C(=O)N(C=2C=C(C=CC2C1C3CCCC3)NCC4CCOCC4)CC=5C=CC=CC5
Molecular Formula
C28H31N3O2
Molecular Weight
441.57
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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