Duocarmycin SA intermediate-1

CAT: 0804-HY-400705Size: InquireDry Ice: NoHazardous: No
CAT#:0804-HY-400705Size:Inquire
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CAS Number
[919535-07-2]
UNSPSC Description
Duocarmycin SA intermediate-1 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-1 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor-suppressive cytotoxicity with proton irradiation[1].
Target Antigen
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/duocarmycin-sa-intermediate-1.html
Solubility
10 mM in DMSO
Smiles
CC(C)(C)OC(N1C2=C(OCC3=CC=CC=C3)C=C(N(C(OC(C)(C)C)=O)C[C@@H]4CO4)C(I)=C2C=C1C(OC)=O)=O
Molecular Weight
678.51
References & Citations
[1]MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. [Content Brief]
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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