Duocarmycin SA intermediate-1

• CAS Number:

  919535-07-2

• UNSPSC Description:

  Duocarmycin SA intermediate-1 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-1 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor-suppressive cytotoxicity with proton irradiation[1].

• Target Antigen:

  Antibiotic

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/duocarmycin-sa-intermediate-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC(C)(C)OC(N1C2=C(OCC3=CC=CC=C3)C=C(N(C(OC(C)(C)C)=O)C[C@@H]4CO4)C(I)=C2C=C1C(OC)=O)=O

• Molecular Weight:

  678.51

• References & Citations:

  [1]MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. [Content Brief]

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported