Duocarmycin SA intermediate-2

Duocarmycin SA intermediate-2

• CAS Number: 2209030-98-6
• UNSPSC Description: Duocarmycin SA intermediate-2 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-2 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor suppressor cytotoxicity with proton irradiation[1].
• Target Antigen: Antibiotic
• Type: Reference compound
• Related Pathways: Anti-infection
• Applications: Cancer-programmed cell death
• Field of Research: cancer
• Assay Protocol: https://www.medchemexpress.com/duocarmycin-sa-intermediate-2.html
• Solubility: 10 mM in DMSO
• Smiles: C[Si](C(C)(C)C)(C)OCC1=CN(S(C2=CC=C(C)C=C2)(=O)=O)C3=C1C=CC(OCC4=CC=CC=C4)=C3
• Molecular Weight: 521.74
• References & Citations: [1]MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. [Content Brief]
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported