Duocarmycin SA intermediate-2

• CAS Number:

  2209030-98-6

• UNSPSC Description:

  Duocarmycin SA intermediate-2 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-2 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor suppressor cytotoxicity with proton irradiation[1].

• Target Antigen:

  Antibiotic

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  Cancer-programmed cell death

• Field of Research:

  cancer

• Assay Protocol:

  https://www.medchemexpress.com/duocarmycin-sa-intermediate-2.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[Si](C(C)(C)C)(C)OCC1=CN(S(C2=CC=C(C)C=C2)(=O)=O)C3=C1C=CC(OCC4=CC=CC=C4)=C3

• Molecular Weight:

  521.74

• References & Citations:

  [1]MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. [Content Brief]

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported