Duocarmycin SA intermediate-2

CAT: 0804-HY-400706Size: InquireDry Ice: NoHazardous: No
CAT#:0804-HY-400706Size:Inquire
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CAS Number
[2209030-98-6]
UNSPSC Description
Duocarmycin SA intermediate-2 is an intermediate in the synthesis of the antibiotic Duocarmycin SA (HY-12456). Duocarmycin SA intermediate-2 induces sequence-selective alkylation of double-stranded DNA and has synergistic, tumor suppressor cytotoxicity with proton irradiation[1].
Target Antigen
Antibiotic
Type
Reference compound
Related Pathways
Anti-infection
Applications
Cancer-programmed cell death
Field of Research
cancer
Assay Protocol
https://www.medchemexpress.com/duocarmycin-sa-intermediate-2.html
Solubility
10 mM in DMSO
Smiles
C[Si](C(C)(C)C)(C)OCC1=CN(S(C2=CC=C(C)C=C2)(=O)=O)C3=C1C=CC(OCC4=CC=CC=C4)=C3
Molecular Weight
521.74
References & Citations
[1]MacMillan KS, et al. Synthesis and evaluation of a thio analogue of duocarmycin SA. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6962-5. [Content Brief]
Shipping Conditions
Room temperature
Clinical Information
No Development Reported

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