JAK1/TYK2-IN-4

• CAS Number:

  2734918-33-1

• UNSPSC Description:

  JAK1/TYK2-IN-4 is a dual inhibitor of JAK and TYK2, with IC50s of 39 nM and 21 nM, respectively. JAK1/TYK2-IN-4 has oral bioavailability[1].

• Target Antigen:

  JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/jak1-tyk2-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=C(N2CCC3(C(NCC3)=O)CC2)N=C(NC4=CN(C)N=C4)N=C1

• Molecular Weight:

  341.41

• References & Citations:

  [1]Xue Cui, et al. Therapeutic potential of a synthetic dual JAK1/TYK2 inhibitor in inflammatory bowel disease. Int Immunopharmacol. 2023 Nov 20:126:111238.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported