JAK1/TYK2-IN-1

JAK1/TYK2-IN-1

• CAS Number: 1883300-48-8
• UNSPSC Description: JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 (IC50 = 29 and 41 nM respectively).
• Target Antigen: JAK
• Type: Reference compound
• Related Pathways: Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/jak1-tyk2-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C([C@H]1C(F)(C1)F)N[C@]23[C@](CN(C4=NC(NC5=CN(C)N=C5)=NC=C4F)C3)([H])[C@H]2C
• Molecular Weight: 407.39
• References & Citations: [1]Fensome A, et al. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg Med Chem. 2020 May 15;28(10):115481.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported