JAK1/TYK2-IN-1

• CAS Number:

  1883300-48-8

• UNSPSC Description:

  JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 (IC50 = 29 and 41 nM respectively).

• Target Antigen:

  JAK

• Type:

  Reference compound

• Related Pathways:

  Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/jak1-tyk2-in-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C([C@H]1C(F)(C1)F)N[C@]23[C@](CN(C4=NC(NC5=CN(C)N=C5)=NC=C4F)C3)([H])[C@H]2C

• Molecular Weight:

  407.39

• References & Citations:

  [1]Fensome A, et al. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg Med Chem. 2020 May 15;28(10):115481.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported